Welcome to CCAAM / CaCVAM

The Canadian Centre for Alternatives to Animal Methods (CCAAM) and the Canadian Centre for the Validation of Alternative Methods (CaCVAM) aim to develop, validate, and promote non-animal, human biology-based platforms in biomedical research, education, and chemical safety testing.

Experimental animals continue to serve as the gold standard in biomedical research today, but many breakthroughs in research labs do not make it into our clinics—95% of drugs tested to be safe and effective in animals fail in human clinical trials. Similarly, for evaluating the safety of chemicals, the legacy animal-based methods are not sufficiently reliable to accurately predict adverse outcomes on human health and the environment.

From the Americas to the Far East, countries across the globe have already established national centres dedicated to non-animal alternatives and approved legislation to shift away from animal testing, but Canada has lagged behind, until now—our Centre is the first-of-its-kind in Canada.

We promote a paradigm shift in which human biology serves as the gold standard.

Time to change the gold standard.

Time to place Canada on the map.

We are deeply grateful to Eric and Dana Margolis for their incredibly generous gift that will transform CCAAM/CaCVAM:

TEDx talk by Dr. Charu Chandrasekera, executive director of CCAAM/CaCVAM "It's time to think outside the cage"