Dr. Matthew Krause
Phone (519) 253-3000 ext: 2443
Office: H.K. Building, Room 119
Postdoctoral Fellowship, SickKids Research Institute, Developmental and Stem Cell Biology program, 2014
Ph.D., McMaster University, Medical Sciences
(Skeletal Muscle Physiology), 2011
M.Sc., University of Western Ontario, Kinesiology
(Exercise Biochemistry), 2006
B.Sc., University of Western Ontario, Kinesiology, 2004
Dr. Krause obtained Kinesiology degrees from the Bachelor’s and Master’s programs at UWO before moving on to do his Ph.D. in the Medical Sciences program at McMaster University where he studied skeletal muscle regeneration. During his postdoctoral fellowship at the SickKids Research Institute in Toronto, he broadened his laboratory skill set with the goal of bringing more a detailed understanding of tissue regeneration to a Kinesiology program. Dr. Krause joined the Faculty of Human Kinetics in the summer of 2015.
Dr. Krause’s teaching interests lie in exercise physiology, skeletal muscle physiology, metabolism and metabolic diseases. Dr. Krause’s research broadly aims to answer the question of how damaged tissues regenerate and how the regeneration process is regulated via extracellular factors. Obesity, diabetes, and aging lead to poor tissue regeneration, particularly in skeletal muscle, resulting partly from a spectrum of alterations in levels of various hormones/signaling factors.
Dr. Krause’s research approaches this problem with two main goals:
1) identify the mechanisms underlying impaired skeletal muscle regeneration in those disease states
2) determine the effect of acute and chronic exercise on expression levels of certain hormones and the subsequent effect on regenerative capacity.
Key Scholarly Activities:
Krause MP, Dworski S, Feinberg K, Jones K, Johnston APW, Paul S, Peles E, Bagli D, Kaplan DR and Miller FD. Direct genesis of functional rodent and human Schwann cells from skin mesenchymal precursors. Stem Cell Reports. 2014 July; 3:85-100.
Thomas MM, Wang DC, D’Souza DM, Krause MP, Layne AS, Criswell DS, O’Neill HM, Connor MK, Anderson JE, Kemp BE, Steinberg GR and Hawke TJ. Muscle-specific AMPK β1-β2-null mice display a myopathy due to loss of capillary density in non-postural muscles. FASEB J. 2014 May;28(5):2098-107.
Krause MP, Al-Sajee D, D’Souza DM, Rebalka IA, Moradi J, Riddell MC, Hawke TJ. Impaired macrophage and satellite cell infiltration occurs in a muscle-specific fashion following injury in diabetic skeletal muscle. PLoS One, 2013 Aug 12;8(8):e70971.
Krause MP, Moradi J, Nissar AN, Riddell MC, Hawke TJ. Inhibition of plasminogen activator inhibitor-1 (PAI-1) restores skeletal muscle regeneration in untreated diabetic mice. Diabetes. 2011 Jul;60(7):1964-72.
Krause MP, Riddell MC, Hawke TJ. Review. Effects of type 1 diabetes mellitus on skeletal muscle: clinical observations and physiological mechanisms. Pediatric Diabetes. 2011 Jun;12(4 Pt 1):345-64.
Krause MP, Riddell MC, Gordon CS, Imam SA, Cafarelli E, Hawke TJ. Diabetic myopathy differs between Ins2Akita+/- and streptozotocin-induced type 1 diabetic models. Journal of Applied Physiology. 2009 May;106(5):1650-9.
Krause MP, Liu Y, Vu V, Chan L, Xu A, Riddell MC, Sweeney G, Hawke TJ. Adiponectin is expressed by skeletal muscle fibers and influences muscle phenotype and function. American Journal of Physiology: Cell Physiology. 2008 Jul; 295(1):C203-12.