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Faculty - Siyaram Pandey

Dr. Siyaram Pandey -  Biochemistry

Dr. Siyaram Pandey

Biochemistry Ph.D. (J.N.U., New Delhi)
spandey@uwindsor.ca
Professor
253-3000 Ext. 3701
277-1 Essex Hall
Personal Website


RESEARCH INTERESTS:

In the Pandey Lab, we have four major research areas of interest.

  • Oxidative Stress in Aging and Neurodegeneration.
  • Oxidative Stress in the Fibroblasts from Alzheimer’s Disease Patients.
  • Development of Single Domain Antibodies Against Pro-Apoptotic Proteins (Caspase-3 and Bax) to Block Cell Death Following Stroke.
  • Using Apoptosis Inducers as a Weapon Against Cancer.

For details please visit us at: http://uwindsor.ca/pandey

SELECTED PUBLICATIONS:

88. Caleb Vegh, Simon Pupulin, Darcy Wear, Lauren Culmone, Rachel Huggard, Dennis Ma and, Siyaram Pandey. (2019) Resumption of autophagy by Ubisol-Q10 in PSAF and Tg(APPswe,PSEN1dE9) mice; Implications for inhibition of senescence and neuroprotection. Under review for Oxidative Medicine and Cellular Longevity 2019 MS# 7404815. Under revision.

87. Ivan Ruvinov1, Christopher Nguyen1, Benjamin Scaria1, Caleb Vegh1, Ola Zaitoon1, Kiruthika Baskaran1, Ali Mehaidli1, Malika Nunes2, Siyaram Pandey (2019). Lemongrass extract possesses potent anti-cancer activity against human colon cancers, inhibits tumourigenesis, enhances efficacy of FOLFOX, and reduces its adverse effects. Submitted to “Integrative Cancer Therapies”. MS# ICT-2019-157. Under Revision

86. Krishan Parashar 1, Siddhartha Sood 1, Ali Mehaidli 1, Colin Curran 1, Caleb Vegh1 , Christopher Nguyen 1 , Christopher Pignanelli 1 , Jianzhang Wu 2 , Guang Liang 2 , Yi Wang 2 and Siyaram Pandey (2019) Evaluating the anti-cancer efficacy of a synthetic curcumin analog on human melanoma cells and its interaction with standard chemotherapeutics. Molecules. 2019, 24, 2483: 1-17:  doi:10.3390/molecules24132483 www.mdpi.com/journal/molecules2019. 24

85. Christopher Nguyen1 and Siyaram Pandey (2019) Exploiting mitochondrial vulnerabilities to trigger apoptosis selectively in cancer cells.  Cancers Vol. 11:7: 916-936.

84. Christopher Nguyen1, Ali Mehaidli1, Kiruthika Baskaran1, Sahibjot Grewal1, Alaina Pupulin1, Ivan Ruvinov1, Benjamin Scaria1, Krishan Parashar1, Caleb Vegh1, Siyaram Pandey1*. Dandelion root and lemongrass extracts induce apoptosis, enhance chemotherapeutic efficacy, and reduce tumour xenograft growth in vivo in prostate cancer  (2019) Evidence based Complementary and Alternative medicine.  Accepted.

83. Christopher Nguyen1, Kiruthika Baskaran1, Alaina Pupulin1, Ivan Ruvinov1, Ola Zaitoon1, Sahibjot Grewal1, Benjamin Scaria1, Ali Mehaidli1, Caleb Vegh1, Siyaram Pandey (2018) Hibiscus flower extract selectively induces apoptosis in breast cancer cells and positively interacts with common chemotherapeutics.  BMC Complement Alt. Med. 2019 May 6;19(1):98. doi: 10.1186/s12906-019-2505-9.

82.  Ray, SD, Yang N., Pandey, S., Bello NT. And Gray JP. Apoptosis  BioMED Encyclopedia  https://doi.org/10.1016/B978-0-12-801238-3.62145-1.

81. Caleb Vegh, Dennis Ma, Kyle Stokes, Darcy Wear, Jerome Cohen and Siyaram Pandey (2019).  A Bird’s-Eye View of the Multiple Biochemical Mechanisms that Propel Pathology of Alzheimer’s Disease: Recent Advances and Mechanistic Perspectives on How to Halt the Disease Progression Targeting Multiple Pathways. Journal of Alzheimer’s Disease 69 (2019) 631–649 DOI 10.3233/JAD-181230.

80.   Cory Philion1, Dennis Ma1, Ivan Ruvinov1, Fadi Mansour1, Christopher Pignanelli1, Megan Noel1, Ammar Saleem2, John Arnason2, Mark Rodriguez1, Inderpal Singh1, Jesse Ropat1, Siyaram Pandey1* (2017) Cymbopogon citratus and Camellia sinensis Extracts Selectively Induce Apoptosis in Cancer Cells and Reduce Growth of Lymphoma Xenografts In Vivo.  Oncotarget, 2017.  Nov 18;8(67):110756-110773.

79. Krithika Muthukumaran, Caleb Vegh, Alexandra Margeniean, Annie Kanwar, Nicholas Guilbeault, Alexander Badour, Jerome Cohen, Marianna Sikorska3 and Siyaram Pandey (2018) Ubisol Q10 (a nanomicellar water-soluble formulation of CoQ10) treatment inhibits Alzheimer type behavioral and pathological symptoms in double transgenic mice (TgAPEswe, PSEN1dE9) model of Alzheimer’s disease.  J. Alzheimer’s Disease. 61 (2018) 221–236.

78. Christopher Pignanelli1, Dennis Ma1, Megan Noel1, Jesse Ropat1, Fadi Mansour1, Colin Curran1, Simon Pupulin1, Kristen Larocque1, Jianzhang Wu2, Guang Liang2, Yi Wang2*, and Siyaram Pandey (2017) Selective Targeting of Cancer Cells by Oxidative Vulnerabilities with Novel Curcumin Analogs.  Nature  Scientific reports. 7: 1105 | DOI:10.1038/s41598-017-01230-4

77. Dennis Ma1, Tyler Gilbert1, Daniel Tarade1, Christopher Pignanelli1, Fadi Mansour1, Manika Gupta1, Ian Tuffley1, Sabrina Ma1, Sergey Vshyvenko2, Tomas Hudlicky2, and Siyaram Pandey1 (2017) Exploiting Mitochondrial & Oxidative Vulnerabilities with a Synthetic Analogue of Pancratistatin in Combination with Piperlongumine for Cancer TherapyFASEB J. 2018 Vol. 32, No. 1 Page 417- 430:  PMID: 28928246.

76.  Dennis Ma1, Daniel Tarade1, Tyler Gilbert1, Christopher Pignanelli1, Fadi Mansour1, Scott Adams1, Colin Curran1, Alexander Dowhayko1, Megan Noel1, Melissa Cowell1, Sergey Vshyvenko2, Tomas Hudlicky2, James McNulty3, and Siyaram Pandey1 (2017) Structure Activity Relationship Analysis of Synthetic Analogues of Pancratistatin: Anti-cancer Activity is Dependent on Functional Mitochondrial Complex II and III. Nature Scientific reports.  2017 21;7:42957. doi: 10.1038/srep42957. PMID: 28220885

75. Daniel Tarade, Dennis Ma, Christopher Pignanelli, Fadi Mansour, Daniel Simard, Sean van den Berg, James Gauld, James McNulty, and Siyaram Pandey (2017)  Structurally Simplified Biphenyl Combretastatin A4 Derivatives Produce Potent Anti-Cancer Activity: In Silico Binding Reveals Novel Anchoring Role of Ethylene Linker. PLoS ONE  2017 Mar 2;12(3):e0171806. doi: 10.1371/journal.pone.0171806. eCollection 2017. PMID: 28253265

74. Daniel Taradea, Siyaram Pandey*, James McNulty (2017) Review of Cytotoxic CA4 Analogues that Do Not Target Microtubules: Implications for CA4 Development. Mini reviews in Medicinal Chemistry, 2017, Published on Line ahead of print.  PMID:27156516.

73. Alessia Roma, Matthew Steckle, Leah Nicoletti, Pamela Ovadje, Siyaram Pandey (2015)Selective Induction of Apoptosis by Azadarichta indica Leaf Extract by Targeting Oxidative Vulnerabilities in Human Cancer Cells. J Pharm Pharm Sci. 2015;18(4):729-46.2015.IF: 2.6

72. Ovadje, Pamela, Ammar, Saleem, Hamm, Caroline , Arnason, John Thor, Pandey, Siyaram (2016) PRECLINICAL EVALUATION OF THE SELECTIVE ANTICANCER ACTIVITY OF DANDELION ROOT EXTRACT IN HUMAN CANCER CELLS. Oncotarget 2016 Nov 8;7(45):73080-73100. doi: 10.18632/oncotarget.11485. PMID: 27564258

71. Pamela Ovadje1, Alessia Roma1, Matthew Steckle1, Leah Nicoletti1, John Thor Arnason2 and Siyaram Pandey1. Advances in the Research and Development of Natural Health Products as Main Stream Cancer Therapeutics (2015) Evidence Based Complementary and Alternative Medicine. Volume 2015, Article ID 751348, 12 pages   http://dx.doi.org/10.1155/2015/751348

70. James McNulty,  Sean van den Berg,  Dennis Ma,  Daniel Tarade,  Seema Joshi,  Julia Church, Siyaram Pandey.  Anticancer activity of structurally simplified biaryl analogs of the anticancer agent combretastatin A4. (2014) Bioorganic & Medicinal Chemistry Letters. Bioorg Med Chem Lett. 2014 Nov 11;25(1):117-121. doi: 10.1016/j.bmcl.2014.10.090. [Epub ahead of print]  Jan 1;25(1):117-21. Epub 2014 Nov 11 PMID:25466200

69.  Daniel Lopatin, Nicole Caputo, Chelsey Damphousse, Siyaram Pandey, and Jerome Cohen. Rats Anticipate Broken Rungs on the Elevated Ladder (2015). J. Of Integrative Neuroscience, Mar 2015 Vol.4(1):97-120

68. Ovadje, Pamela1, Ma Dennis1, Tremblay Philip1, Roma Alessia1, Guerrero Jose-Antonio2, Arnason John Thor2, Pandey Siyaram1. Evaluation of the Efficacy & Biochemical Mechanism of Cell Death Induction by Long Pepper Extract Selectively in in-vitro and in-vivo models of Human Cancer Cells (2014). PLoS ONE  2014 Nov 17;9(11):e113250. doi: 10.1371/journal.pone.0113250. eCollection 2014.  PMID: 25401766.

67. Dennis Ma, Kyle Stokes, Kevinjeet Mahngar, Danijela Domazet- Damjanov, Marianna Sikorska, Siyaram Pandey, Inhibition of Stress Induced Premature Senescence in Prensenilin-1 Mutated Cells with Water Soluble Coenzyme Q10. (2014)  Mitochondrion.    Published on line 2014 Jul 15. pii: S1567-7249(14)00095-6. doi: 10.1016/j.mito.2014.07.004. [Epub ahead of print]PMID: 25034304

66. Krithika Muthukumaran, Jessica Smith, Harshil Jasra, Marianna Sikorska, Jagdeep K Sandhu, Jerome Cohen, Daniel Lopatin, Siyaram Pandey (2014) Genetic susceptibility model of Parkinson’s disease resulting from exposure of DJ-1 deficient mice to MPTP: Evaluation of neuroprotection by Ubisol-Q10.  Journal Parkinson’s Disease, 4:523-530.

65. Marianna Sikorska, Patricia Lanthier, Harvey Miller1, Melissa Beyers, Caroline Sodja, Bogdan Zurakowski, Sandhya Gangaraju, Siyaram Pandey and Jagdeep K. Sandhu Nanomicelar formulation of Coenzyme Q10 (Ubisol-Q10) effectively blocks ongoing neurodegeneration in the mouse MPTP model: potential use as an adjuvant treatment in PD, (2014). Neurobiology of Aging2014 Oct;35(10):2329-46

64. Krithika Muthukumaran, Samantha Leahy, Kate Harrison, Marianna Sirkoska, Jagdeep K Sandhu, Jerome Cohen, Corrine Keshan, Daniel Lopatin, Harvey Miller, Henryk Borowy-Borowski, Patricia Lathier, Shelley Wienstock and Siyaram Pandey (2014) Orally delivered water soluble Coenzyme Q10 (Ubisol-Q10) blocks on-going neurodegeneration in rats exposed to paraquat: potential for therapeutic application in Parkinson's disease. BMC Neuroscience 201415:21 (31 January 2014)

63.  Kristen Larocque, Pamela Ovadje, Sinisa Djurdjevic, Mariam Mehdi, James Green, Siyaram Pandey (2014).  Novel Analogue of Colchicine Induces Selective Pro-Death Autophagy and Necrosis in Human Cancer Cells. PLoS ONE 9(1): e87064. doi:10.1371/journal.pone.0087064.

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