Dr. Anthony Bain
Phone: (519) 253-3000 ext: 4069
Office: H.K. Building, Room 132
Dr. Bain joined the Department of Kinesiology in the summer of 2018. Prior to Windsor, Dr. Bain completed his postdoctoral fellowship at the University of Colorado, Boulder, at the Integrative Vascular Biology Laboratory. His current research interests encompass the integrative aspects of human cardiovascular and cerebrovascular function in health and disease, as well as vascular endothelial function in humans exposed to extreme environments.
The broad aim of Dr. Bain’s research program is to partition the mechanisms responsible for vascular endothelial dysfunction leading to cardio and cerebral vascular events - the leading cause of death globally. To better understand basic vascular function in humans, a secondary facet of Dr. Bain’s research program is determining how the peripheral and cerebral vasculature cope and adapt to extreme environmental stressors, such us heat stress and hypoxemia. This latter aspect has taken Dr. Bain’s research program across the globe with studies in high altitude natives (Andeans), as well as in professional breath hold divers from Croatia.
Areas of Research Interest:
- Insufficient sleep and vascular endothelial function
- Cerebrovascular physiology
- Exercise and vascular health
- Heat stress
- Hypoxemia and high altitude
Key Scholarly Activities
For full publication list see: https://www.ncbi.nlm.nih.gov/pubmed/?term=Bain+AR
Bain AR, Drvis I, Dujic Z, MacLeod DB, Ainslie PN. (2018) Physiology of static breath holding in elite apneists. Exp Physiol. 1;103(5):635-651
Bain AR, Ainslie PN, Hoiland RL, Barak OF, Drvis I, Stembridge M, MacLeod DM, McEneny J, Stacey BS, Tuaillon E, Marchi1 N, De Maudave1 AF, Dujic Z, MacLeod DB and Bailey DM. (2018) Competitive apnea and its impact on the human brain; focus on the redox-regulation of blood-brain barrier permeability and neuronal-parenchymal integrity. FASEB. 32(4):2305-2314
Bain AR, Weil BR, Diehl KJ, Greiner JJ, Stauffer BL, DeSouza CA. (2017) Insufficient sleep is associated with impaired nitric oxide-mediated endothelium-dependent vasodilation. Atherosclerosis. 265: 41-46
Lewis NCS, Bain AR, Wildfong KW, Green DJ, Ainslie PN. (2017) Acute hypoxemia and vascular function in healthy humans. Exp Physiol. 102(12): 1635-1646
Bain AR, Ainslie PN, Bammert TD, Hijmans JG, Sekhom M, Hoiland RL, Flück D, Donnelly J, DeSouza CA. (2017) Passive heat stress reduces circulating endothelial and platelet microparticles. Exp Physiol. 102(6): 663-669
Bain AR, Ainslie PN, Barak OF, Hoiland RL, Drvis I, Mijacika T, Bailey DM, Santoro A, DeMasi DK, Dujic Z, MacLeod DB. (2017) Hypercapnia is essential to reduce the cerebral oxidative metabolism during extreme apnea in humans. J Cereb Blood Flow Metab. 37(9): 3231-3242
Bain AR, Ainslie PN, Hoiland RL, Barak OF, Cavar M, Drvis I, Stembridge M, MacLeod DM, Bailey DM, Dujic Z, MacLeod DB. (2016) Cerebral oxidative metabolism is decreased with extreme apnoea in humans; impact of hypercapnia. J Physiol. 594(18): 5317-28.
Hoiland RL, Bain AR, Rieger M, Ainslie PN. (2015) Hypoxemia, oxygen content, and the regulation of cerebral blood flow. Am J Physiol Regu Integr Comp Physiol. 310(5): R398-413
Bain AR, Nybo L, Ainslie PN. (2015) Cerebral vascular control and metabolism in heat stress. Compr Physiol. 5(3): 1345-80
Bain AR, Dujic Z, Hoiland RL, Barak OF, Madden D, Drvis I, Stembridge M, MacLeod DB, MacLeod DM, Ainslie PN. (2015) Peripheral chemoreflex inhibition with low-dose dopamine; new insight into mechanisms of extreme apnea. Am J Physiol Regu Integr Comp Physiol. 309(9): R1162-71
Bain AR, Smith KJ, Lewis NC, Foster GE, Wildfong KW, Willie CK, Hartley GL, Cheung SS, Ainslie PN. (2013) Regional changes in brain blood flow during severe passive hyperthermia: effects of PaCO2 and extracranial blood flow. J Appl Physiol 115(5): 653-9