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Dr. Matthew Krause

Assistant Professor

Phone (519) 253-3000 ext: 2443
Office:  H.K. Building, Room 119
 
Postdoctoral Fellowship, SickKids Research Institute, Developmental and Stem Cell Biology program, 2014
 
Ph.D., McMaster University, Medical Sciences
     (Skeletal Muscle Physiology), 2011
M.Sc., University of Western Ontario, Kinesiology
     (Exercise Biochemistry), 2006
B.Sc., University of Western Ontario, Kinesiology, 2004
 

PACR Lab

 

Bio

Dr. Krause obtained Kinesiology degrees from the Bachelor’s and Master’s programs at UWO before moving on to do his Ph.D. in the Medical Sciences program at McMaster University where he studied skeletal muscle regeneration. During his postdoctoral fellowship at the SickKids Research Institute in Toronto, he broadened his laboratory skill set with the goal of bringing more a detailed understanding of tissue regeneration to a Kinesiology program. Dr. Krause joined the Faculty of Human Kinetics in the summer of 2015. Dr. Krause’s teaching interests lie in exercise physiology, skeletal muscle physiology, nutrition, metabolism, and disease pathophysiology.

Areas of Research Interest

Dr. Krause’s research broadly aims to answer the question of how tissues are maintained and regenerate following injury and how the regeneration process is regulated via extracellular factors (eg: hormones). Diabetes, aging, cancer, and disrupted circadian rhythms lead to poor tissue regeneration, particularly in skeletal muscle, resulting from a spectrum of pathophysiological changes. The goal of this research program is to 1) identify specific mechanisms underlying impaired tissue regeneration in those disease states and 2) determine the effect of acute and chronic exercise on expression levels of certain hormones and the subsequent effect on regenerative capacity.

Recent Sources of Funding

  • Office of Open Learning OER ACE Grant (co-investigator) 2020-2021: Implementing virtual labs in an undergraduate physiology course.
  • CIHR Project Grant (co-investigator) 2019-2024: The role of Schwann cell precursors in non-healing skin wounds.
  • CIBC Fund for Cancer Cachexia Research 2018-2022: Pathophysiological mechanisms of cancer cachexia.
  • NSERC Discovery Grant 2016-2021: Plasminogen activator inhibitor-1-mediated regulation of skeletal muscle regeneration.
     

Scholarly Articles

Krause MP, Milne KJ, Hawke TJ. Adiponectin-Consideration for its Role in Skeletal Muscle Health. Int J Mol Sci. 2019 Mar 27; 20(7), 1528.

Monaco CMF, Hughes MC, Ramos SV, Varah NE, Lamberz C, Rahman FA, McGlory C, Tarnopolsky MA, Krause MP, Laham R, Perry CGR, Hawke TJ. Mitochondrial impairments in skeletal muscle of young adults with type 1 diabetes: early signs of diabetic myopathy. Diabetologia. 2018 Jun;61(6):1411-1423.

D’Souza DM, Zhou S, Rebalka IA, MacDonald B, Moradi J, Krause MP, Al-Sajee D, Punthakee Z, Tarnopolsky MA, Hawke TJ. Decreased satellite cell number and function in humans and mice with Type 1 Diabetes Mellitus is the result of altered Notch signaling. Diabetes. 2016 Oct; 65(10): 3053-61.

Johnston APW, Yuzwa SA, Carr MJ, Mahmud N, Storer MA, Krause MP, Jones K, Paul S, Kaplan DR and Miller FD. Dedifferentiated Schwann Cell Precursors Secreting Paracrine Factors Are Required for Regeneration of the Mammalian Digit Tip. Cell Stem Cell. 2016 Oct; 19(4): 433-448.

Nguyen T, Obeid J, Walker, RG, Krause MP, Hawke TJ, McAssey K, Vandermeulen J, Timmons BW. Fitness and physical activity in youth with type 1 diabetes mellitus in good or poor glycemic control. Pediatric Diabetes. 2015 Feb;16(1):48-57.

Gallagher D, Voronova A, Zander MA, Cancino GI, Bramall A, Krause MP, Abad C, Tekin M, Neilsen P, Allen DC, Scherer S, Keller G, Kaplan DR, Walz K, Miller FD. Ankrd11 is an epigenetic regulator involved in autism that is essential for neural development. Developmental Cell. 2015 Jan 12;32(1):31-42.

Krause MP*, Dworski S*, Feinberg K*, Jones K*, Johnston APW, Paul S, Peles E, Bagli D, Kaplan DR and Miller FD. Direct genesis of functional rodent and human Schwann cells from skin mesenchymal precursors. Stem Cell Reports. 2014 July; 3:85-100. *Equal authorship.

Krause MP, Al-Sajee D, D’Souza DM, Rebalka IA, Moradi J, Riddell MC, Hawke TJ. Impaired macrophage and satellite cell infiltration occurs in a muscle-specific fashion following injury in diabetic skeletal muscle. PLoS One, 2013 Aug 12;8(8):e70971.

Milne KJ, Thorp DB, Krause MP, Noble EG. Core temperature is a greater influence than endogenous 17β-estradiol on the exercise-induced accumulation of myocardial heat shock protein mRNA. Canadian Journal of Physiology and Pharmacology. Can. J. Physiol. Pharmacol. 2011, 89: 855–860.

Krause MP, Moradi J, Nissar AN, Riddell MC, Hawke TJ. Inhibition of plasminogen activator inhibitor-1 (PAI-1) restores skeletal muscle regeneration in untreated diabetic mice. Diabetes. 2011 Jul;60(7):1964-72.

Krause MP, Riddell MC, Hawke TJ. Review. Effects of type 1 diabetes mellitus on skeletal muscle: clinical observations and physiological mechanisms. Pediatric Diabetes. 2011 Jun;12(4 Pt 1):345-64.